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The Secretome and Liquid Biopsy group establishes novel analyses procedures combined with mass spectrometry for the assessment of metabolic phenotypes covering various biomaterials. One major focus are plasma derived tissue-specific extracellular vesicles to assess organ function and drug-related issues in a minimal-invasive manner, while complementary techniques, including isotope tracing and MALDI imaging, will be applied to study metabolic activities within cellular microenvironments. This integrated strategy contributes to drug target characterization, reveals metabolic vulnerabilities, and supports the discovery of novel markers of drug response.

Heads

Dr. Mathias Haag
Research Group Leader Secretome and Liquid Biopsy
Tel+49-711-8101-5429
mathias.haag@ikp-stuttgart.de
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Dr. Sylvia K. Neef
Head of Chemical Analytics & Synthesis; Research Group Leader Secretome and Liquid Biopsy
Tel+49-711-8101 5002
sylvia.neef@ikp-stuttgart.de
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Team Members

Dr. Pegah Zahedimaram
Scientist
Tel+49-711-8101 2090
Pegah.Zahedimaram@ikp-stuttgart.de
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Natalie Wahl
PhD Student
Tel+49 711 8101-2092
natalie.wahl@ikp-stuttgart.de
Jeanine Jutzi
PhD Student
jeanine.jutzi@ikp-stuttgart.de
Markus König
Technical Assistant
Tel+49-711-8101-5177
markus.koenig@ikp-stuttgart.de
Kevin Wanek
Technical Assistant
Tel+49-711-8101-7786
kevin.wanek@ikp-stuttgart.de

Selected publications of the Research Group

  • Andersson L, Roggia M, Wangriatisak K, Kozel RS, Brittain HR, Youhanna S, Gil M, Haag M, Lauschke VM, Chemin K, Cosconati S, Kozielewicz P. Structure-based screening and a conformational biosensor identify a GPR183 inverse agonist and an activation switch. Nat Commun, 2026. doi: 10.1038/s41467-026-73857-9.
  • Fu X, Brun A, Dittrich K, Cebo M, Lackner M, Menig-Benzig L-S, Bouzabia B, Rheinlaender J, Banks H, Eysmondt H von, Dötsch T, Schwegmann S, Bucio-Garcia J-A, Nürnberg B, Beer-Hammer S, Schwab M, Schaeffeler E, Hofmann U, Haag M, Rath D, Geisler T, Gawaz M, Bakchoul T, Schäffer TE, Lämmerhofer M, Chatterjee M. Targeting ACKR3/CXCR7 Enhances Platelet Anticoagulant Acylcarnitines and Modulates Procoagulant Function. Blood, 2026. doi: 10.1182/blood.2025030939.
  • Neef SK, Opara JF, Heinkele G, Gross MW, Hofmann U, Schwab M, Zimmermann M, Haag M, Mürdter TE. Quantitative analysis of underivatised short-chain fatty acids and simultaneous non-targeted metabolic profiling by ultra-high performance liquid chromatography-mass spectrometry. Microchemical Journal(221):116757, 2026. doi: 10.1016/j.microc.2025.116757.
  • Franzin M, Lagatolla C, Forgiarini SS, Haag M, Neef SK, Comar M, Schaeffeler E, Bellich B, Bramuzzo M, Decorti G, Lucafò M, Hofmann U, Schwab M, Stocco G. Klebsiella pneumoniae contributes to altered cytotoxicity of thiopurines in vitro: Possible implications of biotransformation and bacterial metabolism. Br J Pharmacol. 18(182):4281–4298, 2025. doi: 10.1111/bph.70089.
  • Ghallab A, Myllys M, González D, Friebel A, Hobloss Z, Hassan R, Schmidt H, Siddiqui Q, Zhipeng D, Hendawi R, Begher-Tibbe B, Reinders J, Derksen K, Hofmann U, Duda JC, Ameis L, Möllenhoff K, Seddek A, Abdelmageed N, Strängberg E, Åkerblad P, Vucur M, Luedde T, Stirnimann G, Schwab M, Abbas T, Hild B, Schmidt H, Karpen SJ, Simbrunner B, Mandorfer M, Rahnenführer J, Edlund K, Hoehme S, Trauner M, Dawson PA, Lindström E, Hengstler JG. Stage-dependent effects of systemic ASBT inhibition in a cholestasis-induced cholemic nephropathy mouse model. JHEP Rep. 12(7):101599, 2025. doi: 10.1016/j.jhepr.2025.101599.
  • Haag M, Winter S, Kemas AM, Tevini J, Feldman A, Eder SK, Felder TK, Datz C, Paulweber B, Liebisch G, Burk O, Lauschke VM, Aigner E, Schwab M. Circulating metabolite signatures indicate differential gut-liver crosstalk in lean and obese MASLD. JCI Insight. 8(10, 2025. doi: 10.1172/jci.insight.180943.
  • Menig-Benzig L-S, Stühler V, Mazzola P, Heinrich H, Hofmann U, Widmann N, Bohnert R, Neef SK, Sauter-Meyerhoff C, Schmees C, Fuhr A, Klumpp V, Rausch S, Gürgen D, Mürdter TE, Winter S, Büttner FA, Kruck S, Choffart A, Martins AF, Hennenlotter J, Barcena ML, Vakhrusheva O, Bahlinger V, Fend F, Tsaur I, Bedke J, Schwab M, Schaeffeler E. Drug targeting of the monocarboxylate transporter MCT4 is a novel treatment strategy for metastatic ccRCC. Pharmacol Res(222):108057, 2025. doi: 10.1016/j.phrs.2025.108057.
  • Zwirner S, Abu Rmilah AA, Klotz S, Pfaffenroth B, Kloevekorn P, Moschopoulou AA, Schuette S, Haag M, Selig R, Li K, Zhou W, Nelson E, Poso A, Chen H, Amiot B, Jia Y, Minshew A, Michalak G, Cui W, Rist E, Longerich T, Jung B, Felgendreff P, Trompak O, Premsrirut PK, Gries K, Muerdter TE, Heinkele G, Wuestefeld T, Shapiro D, Weissbach M, Koenigsrainer A, Sipos B, Ab E, Zacarias MO, Theisgen S, Gruenheit N, Biskup S, Schwab M, Albrecht W, Laufer S, Nyberg S, Zender L. First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure. Cell. 7(187):1666-1684.e26, 2024. doi: 10.1016/j.cell.2024.02.023.
  • Neef SK, Hofmann U, Mürdter TE, Schwab M, Haag M. Performance comparison of narrow-bore and capillary liquid-chromatography for non-targeted metabolomics profiling by HILIC-QTOF-MS. Talanta(260):124578, 2023. doi: 10.1016/j.talanta.2023.124578.
  • Wedemeyer H, Schöneweis K, Bogomolov P, Blank A, Voronkova N, Stepanova T, Sagalova O, Chulanov V, Osipenko M, Morozov V, Geyvandova N, Sleptsova S, Bakulin IG, Khaertynova I, Rusanova M, Pathil A, Merle U, Bremer B, Allweiss L, Lempp FA, Port K, Haag M, Schwab M, zur Wiesch JS, Cornberg M, Haefeli WE, Dandri M, Alexandrov A, Urban S. Safety and efficacy of bulevirtide in combination with tenofovir disoproxil fumarate in patients with hepatitis B virus and hepatitis D virus coinfection (MYR202): a multicentre, randomised, parallel-group, open-label, phase 2 trial. Lancet Infect Dis. 1(23):117–129, 2023. doi: 10.1016/S1473-3099(22)00318-8.