Career

Company Description
The Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart (Director Prof. Dr. M. Schwab) is operated by the Robert Bosch Foundation. Since its foundation in 1973, the institute has emerged as Germany's largest and most renowned scientific research unit in the field of clinical pharmacology. Main research activities concentrate on the impact of genetic and non-genetic factors on variability of drug response and their contributions to disease progression, particularly related to cancer.

Job Description

• Characterization of primary tumors on different molecular levels using state-of-the-art methods (e.g. genomics, transcriptomics, metabolomics)
• Application and adaption of a broad spectrum of molecular and cell biological techniques, including FACS analyses, immunohistochemistry, and immunofluorescence
• Establishment and characterization of patient-derived tumor models (e.g., organoids)
• Functional testing of drug effects using in vitro and pre-clinically relevant in vivo models
• Analysis of clinical and experimental datasets (e.g., immunohistochemistry, gene expression) using established biostatistics and bioinformatics approaches
• A close link to clinical aspects of cancer research as primary research aim

Qualifications

• Doctoral degree (e.g., PhD, Dr. rer.nat.) in biology, biochemistry, molecular medicine, pharmaceutical sciences or a related discipline
• Experience and strong background in molecular biology, human genetics and cell culture technology
• Hands on experience with 3D cell culture and in vivo tumor models would be beneficial
• Experience with ”omics” analyses and data interpretation (next-generation sequencing, transcriptomics, metabolomics)
• Interest in oncology and personalized medicine
• Excellent English written and oral communication skills and experience in writing scientific articles

Additional Information

• The opportunity to work in an interactive and interdisciplinary team
• State-of-the-art equipment and innovative technologies for a wide range of different applications (genomics, transcriptomics, metabolomics) and expert knowledge within the different core facilities at the institute
• The opportunity to communicate scientific results at international conferences and to participate in workshops
• Flexible starting date (earliest starting date as of now)
• We offer the opportunity for personal academic career development

For further information please contact:
Prof. Dr. Matthias Schwab (phone 0711-8101-3700) and Dr. Elke Schäffeler (phone 0711-8101-3729).

Send your application via:
Post Doc in Pharmaco-Omics of cancer (m/f/d)

Company Description
The Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart (Director Prof. Dr. M. Schwab) as part of the Bosch Health Campus is operated by the Robert Bosch Foundation. Since its foundation in 1973, the institute has emerged as Germany's largest and most renowned scientific research unit in the field of clinical pharmacology. Main research activities concentrate on the influence of genetic and non-genetic factors on variability of drug efficacy and their contributions to disease development. The core facility Chemical Analytics and Synthesis is looking for a

Postdoctoral Scientist in Mass Spectrometry-Based Proteomics (m/f/d)

Main focus of the core facility is the development and provision of innovative workflows and methods for mass spectrometric analysis of all types of small molecules and lipids in biological materials. To strengthen our expertise in proteomics we are looking for a highly motivated well-trained postdoc in this field.

Job Description

• Establishment of workflows for HR-MS based proteomics from different biological matrices
• Establishment of HR-MS based quantification of endogenous proteins and therapeutic proteins (e.g. monoclonal humanized antibodies)
• Analysis of proteomics datasets using biostatistics and bioinformatics
• Supervision of technicians and master or PhD students

Qualifications

• PhD in chemistry, biochemistry, pharmaceutical sciences or a related discipline
• Experience and solid background in proteomics/protein analysis
• Hands on experience in high resolution mass spectrometry (ideally with Orbitrap mass spectrometer)
• Experience in biostatistical analysis of complex data sets
• Interest in personalized medicine and clinical pharmacology
• Excellent English written and oral communication skills

Additional Information
We offer:

• Opportunities to scientifically develop in an interactive team and an exciting scientific environment
• State-of-the-art equipment in analytical instruments and expert knowledge in statistical data analysis within the biostatistical core facility
• The opportunity to collaborate with experts of other professions (e.g. molecular & cell biologists, clinicians)
• The opportunity to communicate scientific results at international conferences and to participate in workshops

For further information please contact:
Dr. Ute Hofmann (phone 0711-8101-5907), Dr. Thomas Mürdter (phone 0711-8101-5974), or Prof. Dr. Matthias Schwab (phone 0711-8101-3700).

Send your application via:
Postdoctoral Scientist in Mass Spectrometry-Based Proteomics (m/f/d)