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Follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) are the most common subtypes of malignant lymphomas. Their underlying biology is heterogeneous, as evidenced by the marked variability in clinical outcomes. Therapy resistance or relapse occurs in nearly all systemic FL over time and in 30-40% DLBCL patients. Thus, our research aims to identify risk factors and therapeutic targets to optimize clinical interventions, based on our enhanced understanding of the mechanisms driving lymphoma development and progression.

Heads

Prof. German Ott
Professor of Pathology; Head Department of Clinical Pathology; Research Group Leader PharmacoOmics & Lymphoma
Tel+49-711-8101-3390
german.ott@rbk.de
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Dr. Heike Horn
Research Group Leader PharmacoOmics and Lymphoma, Mentoring Program for Thesises
Tel+49-711-8101-5763
heike.horn@ikp-stuttgart.de
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Team Members

Dr. Claudia Kalla
Scientist
Tel+49-711-8101 2099
claudia.kalla@ikp-stuttgart.de
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Dr. Annette Staiger
Scientist
Tel+49-711-8101 5756
annette.staiger@ikp-stuttgart.de
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Sophia Steinlein
PhD Student
Tel+49 711 8101‐2057
sophia.steinlein@ikp-stuttgart.de
Nele Käter
PhD Student
nele.kaeter@ikp-stuttgart.de
Katja Bräutigam
Technical Assistant
Tel+49-711-8101 2099
katja.braeutigam@ikp-stuttgart.de
Herwig Pfeifer
Technical Assistant
herwig.pfeifer@ikp-stuttgart.de

Selected publications of the Research Group

  • Glaser S, Fischer A, Martínez-Manjón JE, López C, Kretzmer H, Burkhardt B, Hübschmann D, Hummel M, Klapper W, Kolarova J, Kreuz M, Ott G, Radlwimmer B, Rosolowski M, Schlesner M, Rosenwald A, Stilgenbauer S, Wagener R, Zwir I, Trümper L, Küppers R, Lichter P, Ammerpohl O, Del Val C, Siebert R. Subgrouping germinal center-derived B-cell lymphomas based on machine learning-deduced DNA methylation modules. Leukemia. 4(39):967–971, 2025. doi: 10.1038/s41375-025-02533-6.
  • Kurz KS, Zamo A, Drewes C, Madej E, Laurent C, Burroni B, Donzel M, Xerri L, Mescam L, Plank L, Gjerdrum LMR, Geyer J, Richter J, Oschlies I, Klapper W, Gramlich S, Doll J, Roth S, Maurus K, Staiger AM, Siebert R, Du M-Q, Rosenwald A, Ott G, Horn H. Cyclin D1 rearranged diffuse large B-cell lymphoma-an evolving concept. Leukemia. 12(39):2988–2996, 2025. doi: 10.1038/s41375-025-02794-1.
  • Kurz KS, Steinlein S, Kreuz M, Ziepert M, Staiger AM, Barth TFE, Möller P, Bernd H-W, Feller AC, Richter J, Klapper W, Stein H, Hartmann S, Hansmann M-L, Trümper L, Loeffler M, Schmitz N, Rosenwald A, Ott G, Horn H. Age- and gender-specific molecular characteristics of diffuse large B-cell lymphoma: Results from clinical trials of the DSHNHL/GLA. Hemasphere. 3(9):e70093, 2025. doi: 10.1002/hem3.70093.
  • Kalla C, Ott G, Finotello F, Niewola-Staszkowska K, Di Conza G, Lahn M, van der Veen L, Schüler J, Falkenstern-Ge R, Kopecka J, Riganti C. The highly selective and oral phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib induces apoptosis in mesothelioma cells and increases immune effector cell composition. Transl Oncol(43):101857, 2024. doi: 10.1016/j.tranon.2023.101857.
  • Noerenberg D, Briest F, Hennch C, Yoshida K, Hablesreiter R, Takeuchi Y, Ueno H, Staiger AM, Ziepert M, Asmar F, Locher BN, Toth E, Weber T, Amini R-M, Klapper W, Bouzani M, Poeschel V, Rosenwald A, Held G, Campo E, Ishaque N, Stamatopoulos K, Kanellis G, Anagnostopoulos I, Bullinger L, Goldschmidt N, Zinzani PL, Bödör C, Rosenquist R, Vassilakopoulos TP, Ott G, Ogawa S, Damm F. Genetic Characterization of Primary Mediastinal B-Cell Lymphoma: Pathogenesis and Patient Outcomes. J Clin Oncol. 4(42):452–466, 2024. doi: 10.1200/JCO.23.01053.
  • Gomez Solsona B, Horn H, Schmitt A, Xu W, Bucher P, Heinrich A, Kalmbach S, Kreienkamp N, Franke M, Wimmers F, Schuhknecht L, Rosenwald A, Zampieri M, Ott G, Lenz G, Schulze-Osthoff K, Hailfinger S. Inhibition of glutaminase-1 in DLBCL potentiates venetoclax-induced antitumor activity by promoting oxidative stress. Blood Adv. 24(7):7433–7444, 2023. doi: 10.1182/bloodadvances.2023010964.
  • Kalmbach S, Grau M, Zapukhlyak M, Leich E, Jurinovic V, Hoster E, Staiger AM, Kurz KS, Weigert O, Gaitzsch E, Passerini V, Engelhard M, Herfarth K, Beiske K, Micci F, Möller P, Bernd H-W, Feller AC, Klapper W, Stein H, Hansmann M-L, Hartmann S, Dreyling M, Holte H, Lenz G, Rosenwald A, Ott G, Horn H. Novel insights into the pathogenesis of follicular lymphoma by molecular profiling of localized and systemic disease forms. Leukemia. 10(37):2058–2065, 2023. doi: 10.1038/s41375-023-01995-w.
  • Steinlein S, Essmann F, Ghilardi AF, Horn H, Schüler J, Hausser A, Sun L, Ott G, Kalla C. Indolyl-chalcone derivatives trigger apoptosis in cisplatin-resistant mesothelioma cells through aberrant tubulin polymerization and deregulation of microtubule-associated proteins. Front Oncol(13):1190988, 2023. doi: 10.3389/fonc.2023.1190988.
  • Horn H, Jurinovic V, Leich E, Kalmbach S, Bausinger J, Staiger AM, Kurz KS, Möller P, Bernd H-W, Feller AC, Koch K, Klapper W, Stein H, Hansmann M-L, Hartmann S, Scheubeck G, Dreyling M, Hiddemann W, Herfarth K, Engelhard M, Rosenwald A, Hoster E, Ott G. Molecular Cytogenetic Profiling Reveals Similarities and Differences Between Localized Nodal and Systemic Follicular Lymphomas. Hemasphere. 9(6):e767, 2022. doi: 10.1097/HS9.0000000000000767.