Microphysiological Tissue Models of Solid Cancer and Microenvironment

Tumor-microenvironment interactions drive therapy resistance and metastasis (de Visser & Joyce, 2023). Using an expanded biobank of paired primary and metastatic tissues, advanced 3D organoids, slice cultures and microfluidic models, we will study the niche-specific interaction between the stroma and immune system to identify targetable biomarkers. Novel therapies, including oncolytic viruses, kinase inhibitors and immunomodulators, will be tested in human preclinical systems. Integrated, multi-or-gan, metastasis-on-chip platforms and -omics analyses will support precision oncology, translating patient-specific findings into early clinical trials.