Chemical Analytics & Synthesis
Portrait
The Core Facility performs state-of-the-art mass spectrometric analyses of small molecules, xenobiotics, and endogenous compounds for all BHC research groups and external collaborators. We offer expertise in ADME research, metabolomics, lipidomics, and proteomics, encompassing sample preparation, data acquisition, data analysis, and interpretation of results, as well as the synthesis of reference materials. Currently, targeted methods for > 250 analytes are available. The Core Facility actively provides expert support to collaboration partners in a holistic manner, covering all steps from experimental design through data acquisition and analysis to raw data storage and interpretation of results. The integrated synthesis department offers the unique opportunity to synthesize reference substances that are not commercially available, such as isotope-labeled internal standards, novel compounds, or their metabolites. Our analytical workflows include rigorous quality control, feature annotation, confident identification and quantification where required, and the application of robust statistical, bioinformatic, and spatial analysis approaches to deliver reliable insights that directly support translational research. For advanced statistical and bioinformatic analyses, as well as PK/PD modeling, we closely collaborate with the Core Facility for Biostatistics, Bioinformatics, Pharmacometrics, and Artificial Intelligence.