Biofabrication

The Biofabrication Core Facility at the IKP, Stuttgart, provides cutting-edge platforms for the gener-ation, characterization, and application of advanced human-relevant 3D tissue models. The facility integrates primary human cell culture, spheroid and organoid systems, biomaterial engineering, and microphysiological technologies to support mechanistic research, drug development, and transla-tional studies. Our established workflows include the generation of scaffold-free and scaffold-based 3D microtissues, bioprinted constructs, and perfused organ-on-chip models. These systems enable functional assessment of drug efficacy, toxicity, metabolism (ADME), inflammation, fibrosis, and regenerative responses under physiologically relevant conditions. The facility supports both hypoth-esis-driven studies and translational projects with academic and industrial partners. A particular fo-cus lies on patient-derived models that preserve inter-individual variability, thereby enabling preci-sion pharmacology and personalized medicine approaches. Complementary analytical IKP platforms -  Chemical Analytics & Synthesis and Molecular Analytics - (e.g., high-content imaging, viability and functional assays, metabolic phenotyping including Sea-horse-based bioenergetic analysis, and multi-omics integration) ensure comprehensive phenotypic characterization of engineered tissues.